Pharmacokinetics Journals

Pharmacokinetics is the branch of pharmacology which is concerned with the effect of drug on the body since it has been administered .The biggest challenge faced by organ transplant is rejection. Immunosuppressive therapy has been used successfully to increase patient survival by reducing incidence of graft rejection and/ or drug-related toxicity. Nonetheless, individual response of organ transplant recipients differs among immunosuppressive drugs using standardized dose regime. Among factors claimed to influence individual responses to drug therapy are disease state, kidney and liver functions, hormonal levels, pharmacokinetic drug-to-drug interactions, diet, life style, and genetic variation.related toxicity. Nonetheless, individual response of organ transplant recipients differs among immunosuppressive drugs using standardized dose regime. Among factors claimed to influence individual responses to drug therapy are disease state, kidney and liver functions, hormonal levels, pharmacokinetic drug-to-drug interactions, diet, life style, and genetic variation.Polymorphisms of SLCO1B1 and SLCO2B1 genes were detected by TaqMan genotyping and were associated to tacrolimus pharmacokinetics. (CamilaAlves, Claudia R Felipe, Alvaro M Nishikawa, Patricia C Salgado, Cristina Fajardo, Helio T Silva Jr, Jose Osmar M Pestana, DenizeZetchak, GlaucioSpinelli, Nagilla Oliveira, Mario Hiroyuki Hirata, Rosario DC Hirata and Alice C Rodrigue, Influence of SLCO1B1 and SLCO2B1 Polymorphisms on Tacrolimus Pharmacokinetics and Clinical Response)

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Last date updated on September, 2024