As the name implies, vasodilator drugs relax the smooth muscle in blood vessels, which causes the vessels to dilate. Dilation of arterial (resistance) vessels leads to a reduction in systemic vascular resistance, which leads to a fall in arterial blood pressure. Dilation of venous (capacitance ) vessels decreases venous blood pressure.
Vasodilators are used to treat hypertension, heart failure and angina; however, some vasodilators are better suited than others for these indications. Vasodilators that act primarily on resistance vessels (arterial dilators) are used for hypertension and heart failure, but not for angina because of reflex cardiac stimulation. Venous dilators are very effective for angina, and sometimes used for heart failure, but are not used as primary therapy for hypertension. Most vasodilator drugs are mixed (or balanced) vasodilators in that they dilate both arteries and veins; however, there are some very useful drugs that are highly selective for arterial or venous vasculature. Some vasodilators, because of their mechanism of action, also have other important actions that can in some cases enhance their therapeutic utility as vasodilators or provide some additional therapeutic benefit. For example, some calcium channel blockers not only dilate blood vessels, but also depress cardiac mechanical and electrical function, which can enhance their antihypertensive actions and confer additional therapeutic benefit such as blocking arrhythmias.
Pharmacology is drug action on living systems mainly pharmacodynamics and pharmacokinetics studies. Pharmacology find new targets, better drugability of the chemical and natural compounds, harnessing the updates of biochemistry, genetics, molecular biology, bioinformatics and personilized medicine. Pharmacology is a journal dedicated to publish research articles in the area of Pharmacodynamics, Pharmacokinetics, AMDE studies of new drug, Toxicology studies, Drugability of the new Chemical and natural compounds and advanced fields like Pharmacogenetics, Pharmacogenomics, Pharmacoepidemiology and Environmental Pharmacology.
Pharmacology science for mutations causing inherited predisposition to breast and ovarian cancer, Tuberose sclerosis, Incontinentia pigmenti, Stickler disease and Lynch syndrome are all carried out routinely by NGS. Further developments are in progress to introduce NGS to replace other existing molecular genetics and cytogenetic tests, and we aim to dramatically increase the number of genes and disorders that we can analyse using this technology in the very near future. Drug discovery is a highly complex and costly process, and in recent years, the pharmaceutical industry has shifted from traditional to genomics- and proteomics-based drug research strategies. The identification of druggable target sites, promising hits, and high quality leads are crucial steps in the early stages of drug discovery projects.
Last date updated on June, 2014