Pregabalin is a structural analogue of gamma-aminobutyric acid (GABA). It acts by presynaptic binding to the α -2-λ subunit of voltage-gated calcium channels that are widely distributed in the spinal cord and brain. This mechanism in pre and post-synaptic membranes leads to inhibition of excitatory neurotransmitters release. Compared with gabapentin, pregabalin due to its better fat solubility and transmission in blood-brain barrier is a more favorable replacement for this drug, with better pharmacokinetic properties and because of less hepatic metabolism, drug interactions are lower with pregabalin. Pregabalin in the treatment of neuropathic pain, incisional pain, aches and inflammatory pain induced by formalin has been used effectively.
Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.
The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.
Last date updated on June, 2014