"Proteomics studies are costly and require a great deal of resources, limiting the number of replicates that can be assessed. Pooling datasets from multiple studies allows the analysis of many more samples and studies with similar conclusion can be validated. Through a systemic review of mass spectrometry based proteomics literature centered around preeclampsia, 53 proteins were detected in at least two of the 12 studies as differentially expressed in preeclamptic patients. Additionally, these were enriched to pathways previously implicatedin the pathology of preeclampsia: hemostasis, immune response, and lipid metabolism.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."
Last date updated on July, 2014