Proteins are the principal targets of small chemical drug molecules. Common applications of proteomics in the drug discovery include target identification and validation, identification of toxicity biomarkers, efficacy estimation and understanding the mode of action of the drug molecules and their toxicity. MS based proteomics technologies are ideally suited for the discovery of biomarkers in the absence of prior knowledge of quantitative and qualitative changes in proteins. Following are the major areas in drug discovery where proteomics have become popular. Vs Nitish Kumar Mishra, Application of Computational Proteomics and Lipidomics in Drug Discovery.
Last date updated on July, 2014