Tuberculosis (TB) remains one of the worldâs major health problems. It is estimated that 8.6 million people developed TB, and 1.3 million died from the disease in 2012. Because of the increased drug-resistance of the causative bacterium M. tuberculosis (Mtb), about a half of the multidrug-resistant tuberculosis (MDR-TB) patients were not successfully treated globally in 2010. Thus, it is urgent to identify novel therapeutic targets for developing drugs that can treat drug-susceptible and drug-resistant TB. Since Mtb is an intracellular pathogen mainly residing in macrophages, thus elucidating the mechanisms underlying Mtb-macrophage interactions is crucial to the development of Mtb-host interfaces-targeted therapeutics.
M. tuberculosis and Macrophages: Co-existence and Co-evolution: Cui Hua Liu
Journal of Pulmonary & Respiratory Medicine welcomes articles related to "Tuberculosis"
Last date updated on June, 2014