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Review Article Open Access
The skin forms the body’s defensive perimeter against what is in reality the biologically hostile environment we humans live in. The delivery of drug through skin has been beneficial for long time due to large surface area of skin which is exposed to vast number of circulatory and lymphatic networks and the routes is easy to access. A topical delivery is one that is applied directly to any external body surface and they are only for localized action. Transdermal drug delivery systems (TDDS) are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. However both topical and transdermal products are intended for external use. But topical products are intended for localized action on one or more layers of the skin whereas transdermal drug delivery systems use the percutaneous route for systemic effect. The delivery of drugs through the skin provides several important advantages over traditional oral and intravenous delivery routes. Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through the skin at predetermined rate with minimal inter and intra patient variability. The discovery of TDDS is a major breakthrough in the field of controlled drug delivery systems. The ability of TDDS to deliver drugs for systemic effect through intact skin while bypassing first pass hepatic metabolism has accelerated transdermal drug delivery research in pharmaceutics.
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Author(s): Darshan Kaur1, Rajinder Singh