alexa Abstract | Antiarthritic Activity of Kanthaga Parpam (KP) (Official Siddha Drug) in Complete Freunds Adjuvant (CFA) Induced Arthritic rats


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Abstract

Periarthritis of the shoulder (frozen shoulder) is the most common problem among aged individuals. It is a well-defined condition with its phases of severe pain, increasing stiffness, and the gradual recovery of full movement of the shoulder. The present study evaluates the safety and anti-arthritic efficacy of herbo-mineral formulation kanthagaparpam (kp) (official siddha drug) in animal models. The anti-arthritic activity of kp (in doses of 25 mg/kg and 50 mg/kg of body wt.) Was evaluated using the complete freund’s adjuvant (cfa) induced arthritis models. Diclofenac sodium (45 mg/kg body wt.) Was used as the standard drug in all the models. This study includes examination of the paws, haematological parameters, body weight changes, organ weight changes and paw withdrawal latency. The lesions were measured again on the 7th, 14th, and 21st days after injection of the adjuvant. The marked reduction of the arthritis score by kanthagaparpam as observed in our study indicates a possible immune suppressant effect .a significant reduction in the levels of the biomarkers of inflammation and autoimmune stimulation in the treated rats. Significant (p<0.05) decrease in mean paw edema level of treated group compare to control. Also significant (p<0.05) decrease in body weight of treated group compare to control. Significantly inhibit the progression of the arthritis in animal models. The present study reveals that the kanthaga parpam (kp) can be more beneficial in the treatment of periarthritis.

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Author(s): P. Parthiban, K. Kanagavalli, P. Sathiyarajeswaran, J. Anbu,G. Krishnaprakash

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