alexa Abstract | Comparison of the Effect of Gabapentin, Topiramate, Levetiracetam and Zonisamide in Vincristine induced Neuropathic Pain in Albino Rats using Chemical Method


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Abstract

Background: Neuropathic pain is a frequently occurring disease. Its treatment is very difficult. Antiepileptic drugs are effective in neuropathic pain acting by central and peripheral mechanism.Objective: The objective of present study was to compare the effect of newer Antiepileptics for treatment of neuropathic pain induced by anticancer drug (vincristine) in albino rats using chemical method. Materials and Methods: Neuropathic pain was induced by injecting vincristine (100μg/kg) intraperitoneally daily for 14 days in rats. Behavioural testing for chemical hyperalgesia was assessed 24 hours after each injection by the writhing test. After 14 days rats were divided into five groups of six animals each. Group I was treated with distilled water as control group, group II was treated with oral gabapentin (60 mg/kg), group III received oral topiramate (40 mg/kg), group IV was treated with oral levetiracetam (120 mg/kg) and group V received zonisamide (50 mg/kg).The antihyperalgesic effect of drugs was assessed by writhing test 24 hours after each administration. Statistical analysis was done by two way analysis of variance (ANOVA) followed by post hoc test. Results: Gabapentin, topiramate, levetiracetam and zonisamidetreated groups showed a significantly (P < 0.0001) reduced number of writhes on writhing test as compared to control group.Conclusion:Newer antiepileptics (gabapentin, topiramate, levetiracetam and zonisamide) are effective inanticancer drugs induced neuropathic pain acting via different mechanisms.

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Author(s): Punam Jakhar, Omi Chouhan, Anusuya Gehlot, R. K. Rathore, Rajesh Chaudhary, Susheel Kumar

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