alexa Abstract | Correlation of Nitric oxide and testicular activity in laboratory mouse, Mus musculus
ISSN ONLINE(2319-8753)PRINT(2347-6710)

International Journal of Innovative Research in Science, Engineering and Technology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


This study helps us to understand the interrelationship between the signaling molecule nitric oxide (NO) and testicular activity. In the first part of the experiment, NO activity (nitrite and nitrate concentration; in the plasma and testes and NOS (nitric oxide synthase) expression; in testis) was analyzed in sexually immature and mature laboratory male mouse, Musmusculus. In the second experiment immature mice were administered with NOS inhibitor N-nitro-larginine methyl ester (L-NAME, 1 mg/100 g body weight) and mature with NO donor sodium nitroprusside (SNP, 0.25 mg/100 g body weight) intraperitoneally for 7 days. In the third experiment, both immature and mature mice were administered with testosterone propionate (TP) for 7 days intramuscularly. Results indicate increased NO level and intense expression of ir-NOS (immunoreactive NOS) in sexually immature mice compared to mature. Although NOS inhibitor has no effect on plasma testosterone level of immature mice; NO donor has suppressed testosterone in mature mice. Further, testosterone injection decreased NO level in both the age groups of mice. It is concluded that NO and gonadal activity exhibit inverse relationship not only in control/ basal condition but experimental induction of increased NO level may suppress gonadal activity while exogenous testosterone may suppress NO activity. These findings not only suggest the inverse NO-gonadal relationships but also indicate that modulation of NO activity may affect gonadal activity and vice versa under different physiological / experimental conditions.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): VineetPrakash Singh, Chandra Mohini Chaturvedi


Nitric oxide, L-NAME, SNP, ir- NOS, Testosterone propionate, Aerospace Engineering,Applied Sciences,Biochemistry,Biogenetic Engineering,Biomedical Engineering,Botany,Fluid Dynamics.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version