alexa Abstract | Effects of Microgravity on the Phenotype, Genome and Transcriptome of Streptococcus pneumonia
E- ISSN: 2320 - 3528
P- ISSN: 2347 - 2286

Research & Reviews: Journal of Microbiology and Biotechnology
Open Access

Like us on: https://twitter.com/BiotechMicrobio
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

Objective: Microgravity can influence pathogenic bacteria by changing their various biological characteristics. However, how microgravity affects Streptococcus pneumoniae as well as the relevant mechanisms remain unclear. Methods: A multiple drug resistant Streptococcus pneumoniae strain was cultured in a microgravity or gravity environment for 16 h. Subsequently, various phenotypic assays were performed, including those for morphology, growth curves, biofilm formation and acid and base stress. A combined genomic and transcriptomic analysis was performed. Results: Compared with gravity and the parental strain, the morphology, growth curve and biofilm formation of the microgravity strain did not change, whereas the microgravity strain had increased resistance to weak acid and base solutions and lost the ability to utilize glucuronamide. Comparative genomic and transcriptomic analyses revealed that the microgravity strain had changes in gene expression related to metabolism, cell wall/capsule and cell defense mechanisms. Conclusion: Our study reveals microgravity has a significant influence on metabolism and adaptation in the Streptococcus pneumoniae, which exhibit great flexibility and adaptability to survive successfully via the regulation of multiple physiological functions and cellular pathways. It may provide new understanding of space microbiology.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Jia Li, Yinghua Guo, Guogang Xu, Xuelin Zhang, Lei Pan, Hong Zhong, Chou Xu, Changting Liu

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords