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Research Article Open Access
Alanine transaminase (ALT) is a transaminase enzyme found in serum and in various body tissues. Elevated levels of ALT suggest the existence of disease such as liver damage, diabetes etc. Hyperoside, β-sitosterol was taken as ligand for molecular docking with Type 2 diabetic targets. Alanine transaminase enzyme whose crystallographic structures are available on the PDB database as 3IHJ was used for the docking analysis using the Schrodinger tool. The docking studies of the enzyme Alanine transaminase with two ligand hyperoside and β-sitosterol reveals that these are the good molecules which docks well with targets related to diabetes mellitus. Metformin is used as a standard drug for docking with Alanine transaminase. Hence hyperoside and β-sitosterol can be considered for developing into antidiabetic drug.
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Author(s): M. Uma Makheswari, D. Sudarsanam