alexa Abstract | Prevalence of HPV Proteins in Esophageal Squamous Cell Carcinoma from Tang Shan of China: An Immunohistochemistry Study
E- ISSN: 2320 - 3528
P- ISSN: 2347 - 2286

Research & Reviews: Journal of Microbiology and Biotechnology
Open Access

Like us on: https://twitter.com/BiotechMicrobio
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The presence of HPV DNA in cases of esophageal squamous-cell carcinoma has been reported repeatedly from Tangshan area of China and other regions with a high incidence of esophageal carcinoma. In current study, to investigate the presence of human papillomavirus in esophageal squamous cell carcinoma, 112 formalin fixed paraffin-embedded tissue samples of ESCC from Tangshan were evaluated for HPV16/18E6, HPV16/18E7, P16 and P21 proteins by Immunohistochemistry method. 112 samples divided to two HPV PCR positive and negative groups of 83 and 29 cases respectively. From 83 slides of PCR positive group 73(87.95%), 48(57.83%), 75(90.36%) and 72(86.74%) of slides had positive reaction for HPV16/18 E6, HPV16/18E7, P21 and P16 respectively. From 29 PCR negative cases 14(48.27%) and 15(51.72%) showed positive staining reaction for P16 and P21 respectively. Results showed a good direct relation between expression of two common cancerous proteins, P16 and P21, and HPV specific proteins by higher positive slides of 72/83 (86.74%) for P16 and 75/83 (90.36%) for P21 in group of positive HPV PCR, in compare with the lower positive result in negative HPV PCR group of 15/29 (51.72%) and 14/29 (48.27%) for P16 and P21 respectively. In this study, P16 and P21 were implicated as two good markers with high expression in ESCC cancerous tissue with HPV infection probability. Findings in this study raise the possibility that HPV is involved in esophageal carcinogenesis. Further investigation with a large sample size over different areas may be warranted.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Mohammadreza Mohammadzad Mehryar, Fan Li, Jintao Li, Shu Ying Li, Hongwei Liu, Fang Zhang, Yubai Zhou and Yi Zeng

Keywords

Immunohistochemistry, Esophageal squamous-cell carcinoma, Esophageal carcinoma, Human papillomavirus, Formalin fixed paraffinembedded tissue, HPV, Carcinoma, Immunohistochemistry, histochemistry, Cell Carcinoma , Molecular Diagnosis, Personalized Medicine, Medicinal Biotechnology, Clinical Microbiology Research, Clinical Microbiology Reviews, Clinical Microbiology and Infection, Clinical Microbiologist, Manual of Clinical Microbiology, Clinical Microbiology Case Reports, Antimicrobial Activity, Antimicrobial Agents, Antimicrobial Suceptibility

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords