alexa Abstract | Review on Needle Free Drug Delivery Systems


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Review Article Open Access

Abstract

Needle-free liquid jet injectors have been used for more than 50 years for parenteral delivery of vaccines and drugs. Although excellent bioavailability has been reported for a number of drugs, occasional pain and bruising have limited wide acceptance of jet injectors. This article reviews jet injectors with respect to their current clinical applications, emerging applications, mechanistic understanding and future prospects. The researchers say that among other benefits, the technology may help reduce the potential for needle-stick injuries; the Centers for Disease Control and Prevention estimates that hospital-based health care workers accidentally prick themselves with needles 385,000 times each year. A needleless device may also help improve compliance among patients who might otherwise avoid the discomfort of regularly injecting themselves with drugs. A needleless device may also help improve compliance among patients who might otherwise avoid the discomfort of regularly injecting themselves with drugs. This narrative review aims to discuss about the needle less injection, their applications and advantages over needle injections. A comprehensive and thorough literature review was done about needle free injections technologies and needle free injection devices currently available on the market and the information regarding it was clearly placed in this article. The main drawbacks of needle injections that prompt scientists to look for the needle less injections were explained. An overview of recent trends and other needleless drug delivery systems was also explained.

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Author(s): Bhagyashri Chavan, Abha Doshi, Yashwant Malode, Balu Misal

Keywords

Microjets, needle free devices, needleless injection, powder jets, pulsed microjets, shock waves., Liver Inflammation

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