alexa Abstract | Synthesis and Anticonvulsant Activity of Indolo-Imidazolone Hybrid Molecules

Research & Reviews: Journal of Medicinal & Organic Chemistry
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Research Article Open Access


A series of hybrid molecules comprising of indole and imidazolone moieties (4a-g and 5a,b) was synthesized with a view to obtain promising anticonvulsant molecules. Anticonvulsant activity of the title compounds was determined in MES and scPTZ animal models. Neurotoxicity studies were also performed to estimate the undesired effects of the compounds. Majority of the compounds showed appreciable activity against both the animal models whereas compounds 5a and 5b showed good activity and could be considered as leads for further investigations

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Author(s): Asif Husain, Aftab Ahmad, Fahad Al-Abbasi, Shah Alam Khan


Indole, imidizalolone, Mice, Anticonvulsants, Indole, imidizalolone, Mice, Anticonvulsants.

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