alexa Abstract | Synthesis and Antiplatelet Aggregation Activities in Vitro of N,N-di(3-Substitutedphenyl)-4-Methoxyl Benzene-1,3-Disulfonamides
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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On the principles of isosterism and for the new antiplatelet aggregating drug purposes, nineteen N,N’-di(3-substitutedphenyl)-4-methoxylbenzene-1,3-disulfonamides of series 2 were synthesized by two steps of reactions including chlorosulfonation and ammonolysis. There in vitro anti-platelet aggregation activities were evaluated by Born test and in comparison with their structure analogues of 4-methoxyisophthalamides of series 1. Results among the series 2 screened, compound 4n has the highest activity and 7 compounds (4b, 4d, 4g, 4h, 4j, 4n and 3h) have higher activities than that of the control drugs both Picotamide and Aspirin.

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Author(s): Xiu Jie Liu*, Chao Qing Wang, Xiao Wang, Qing Xiang Zhang , Kai Liu


N,N’-di(3-substituted-phenyl)-4-methoxylbenzene-1,3-disulfonamides, Activity in vitro, Antiplatelet aggregation, Synthesis, N,N?-di(3-substituted-phenyl)-4-methoxylbenzene-1,3-disulfonamides, Activity in vitro, Antiplatelet aggregation, Synthesis

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