" Secretomics describes the global study of proteins that are secreted by a cell, a tissue or an organism, and has recently emerged as afield for which interest is rapidly growing. The term secretome wasfirst coined by Tjalsma et al. at the turn of the millennium andwas defined to comprise not only the native secreted proteins but thecomponents of machineries for protein secretion as well. Greenbaum etal. narrowed down the definition of secretome to âthe population ofgene products that are secreted from the cellâ. More recently, Agrawalet al. refined secretome as âthe global group of secreted proteinsinto the extracellular space by a cell, tissue, cell, organ or organism atany given time and conditions through known and unknown secretorymechanisms involving constitutive and regulated secretory organellesâ. Two secretory pathways have been described in fungi: i) the canonical pathway through which proteins bearing a N-terminal peptide signal.
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Last date updated on July, 2014