Newcastle disease is an acute viral disease of domestic poultry and many other bird species. It is a worldwide problem that presents primarily as a respiratory disease, but depression, nervous manifestations, or diarrhea may be the predominant clinical form. Mortality is variable. Newcastle disease is caused by an RNA virus, Newcastle disease virus (NDV), synonymous with avian paramyxovirus-1 which is in the genus Avulavirus, family Paramyxoviridae. Isolates are classified into 1 of 3 virulence groups by chicken embryo and chicken inoculation as virulent (velogenic), moderately virulent (mesogenic), or of low virulence (lentogenic). Lentogenic strains are used widely as live vaccines in healthy chickens. Clinical manifestations vary from high morbidity and mortality to asymptomatic infections. Virulent NDV strains are endemic in poultry in most of Asia, Africa, and some countries of North, Central, and South America. Other countries, including the USA and Canada, are free of those strains and maintain that status with import restrictions and eradication by destroying diseased poultry.
Transgenic Plant Vaccine: A Breakthrough in Immunopharmacotherapeutics: Awale MM, Mody SK, Dudhatra GB, Avinash Kumar, Patel HB, Modi CM, Kamani DR and Chauhan BN
Last date updated on July, 2014