Secretory IgA

Secretory IgA is the principal immune component of major and minor gland salivary secretions and thus would be considered to be the primary mediator of adaptive immunity in the salivary milieu apart from other immunoglobulins like IgG and IgM which are derived from the gingival circular fluid. In addition to this, gingival sulcus also contains various cellular components of the immune system like lymphocytes, macrophages and neutrophils. Some of the possible ways by which salivary IgA antibodies act against mutans streptococci. The family of adhesions from Streptococcus mutans and Streptococcus sobrinus has been shown to be effective antigens. The salivary IgA may act as specific agglutinin acting with the bacterial surface receptors and inhibiting colonization and subsequent caries formation. In addition, they mayalso inactivate surface glucosyltransferase which cansignificantly influence the disease outcome, presumably by interference with one or more of the functional activities of the enzyme resulting in reduce amount of the plaque. The second important mechanism involves the migration of antigen-sensitized IgA precursor B cells from Gut-Associated Lymphoid Tissues to salivary glands. The GALT, including numerous solitary lymphoid nodules and particularly Peyer’s patches, are a rich source of precursor IgA B cells that have the potential to populate distant lymphoid tissues and the salivary glands. These have the potential to inhibit the activity of GTF.

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Last date updated on September, 2024