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Varicella Pneumonia in an Immunocompetent Adult: A Case Report
The clinical presentation of varicella in adults is frequently associated with complications, particularly varicella pneumonia. Most cases occur in immunocompromised adults but immunocompetent can have serious pulmonary compromise. We report the case of an immunocompetent patient admitted to the intensive care unit with dyspnea .. Read More
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Cancer of Unknown Primary Site: Not All is Lost!
A Cancer of Unknown Primary Site (CUPS) is defined as a metastatic tumor for which the site of origin remains unknown after establishing tissue diagnosis despite a standard diagnostic approach. It is still not known whether CUP is an entity with dormancy of primary as its hallmark or a distinct entity with specific genetic aberr.. Read More
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Pharmacovigilance Observed: Why Watchful Waiting will Work
This paper reviews issues of pharmacovigilance, defined as “all scientific and data gathering activities relating to the detection, assessment, and understanding of adverse events”, including pharmacoepidemiologic studies, which are “undertaken with the goal of “identifying adverse events and understandin.. Read More
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Factors Affecting the Clinical Use of Non-Invasive Prenatal Testing
Non-invasive prenatal testing (NIPT) is a technique first developed in the early 1990’s that enables testing of a fetus for genetic conditions, based on a sample of maternal blood [1]. Small fragments of extracellular DNA from both mother and fetus are present in maternal plasma, and by excluding fragments of maternal orig.. Read More
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Purpose: This study sought to establish the outcome following percutaneous transluminal angioplasty (PTA) in patients with critical limb ischemia (CLI) and how diabetes may influence that outcome. Method: A retrospective study included 49 consecutive patients with CLI who were managed by PTA between 2008 and 2011, with a follow-.. Read More
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Global emergence of Acinetobacter baumannii (A. baumannii) displays a mechanism of resistance to all existing antimicrobials. Objective of this study was to investigate the effect of biofield treatment on antimicrobial sensitivity pattern, minimum inhibitory concentration (MIC), biochemical reactions and biotype number of A. bau.. Read More
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May-Thurner syndrome is a unique condition that strikes mainly young people. Its prevalence is likely underestimated and perhaps ranges from 22 to 32%. May-Thurner is under reported and often miss-diagnosed in accident and emergency, which can result in long term complication (post thrombotic syndrome) with its detrimental effec.. Read More
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Cancer is a disease of the genome. The first evidence for the role of genetics in cancer causation was identification of Philadelphia chromosome in chronic myeloid leukaemia [1] and now we are in such a state that we can create neoplastic cells in the laboratory through genetic manipulation of normal cells. Normal cells can be t.. Read More
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Diarrhea as the Main Initial Manifestation of Meningococcemia: 2 Case Reports
Invasive meningococcal infections show a broad clinical picture in sepsis and meningitis. The clinical reports of the disease do not include diarrhea as an initial clinical presentation, since it is only seldom reported. Here is a description of two cases of meningococcal infection with diarrhea as the main initial clinical mani.. Read More
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A Rare Case of Prostatic Extra Gonadal Germ Cell Tumor in a Young Adult: Review of the Literature
We report the case of a 29 year-old male who presented with hemospermia. A biopsy revealed an embryonal rhabdomyosarcoma of the prostate and the patient was treated with pre-operative chemotherapy according to the pediatric protocol IVAD (Ifosfamide - Actinomycin - Doxorubicin – Vincristine) followed by prostatectomy. Path.. Read More
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Genetic Aspects of Cleft Lip and Palate – A Review
Craniofacial abnormalities especially Cleft Lip and Palate (CLP) are considered to be one of the most commonly occurring birth defects in humans. CLP is considered to be a very important disorder to be understood because of the the complications it produces in an infant. Recent advances in molecular techniques has given a good i.. Read More
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Necrotising pneumonia caused by Panton-Valentine Leukocidin Staphylococcus aureus confers a high mortality. We describe a child presenting with sepsis and necrotising pneumonia. Septicaemia caused by Panton-Valentine Leukocidin Staphylococcus may not be adequately treated with antibiotics to which it appears sensitive through st.. Read More
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Verrucous Psoriasis and Verrucous Lichen Associated With an Autoimmune Hepatitis
Verrucous psoriasis is a rare form of Psoriasis which has a clinical characteristic and histological appearance. Only few cases have been reported in the literature. We report a rare case of verrucous psoriasis associated with verrucous lichen appeared in a patient with an autoimmune hepatitis... Read More
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We report on a patient who presented with severe myoclonus as a paraneoplastic syndrome due to a renal cell carcinoma. In a patient who had contraindications against definitive extirpative surgery, this is the first instance in which percutaneous cryoablation was used as a successful treatment for the renal cell carcinoma and ne.. Read More
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Background: Collectively, factor V Leiden (FVL, rs6025) and prothromin gene mutation (PGM, rs1799963) are responsible for the majority of inherited thrombophilic states in Caucasians. Patients with inherited thrombophilias are at a greater risk of unprovoked venous thromboembolic events. As such, testing for these abnormalities .. Read More
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Background: The purpose of this study was to evaluate the performance of the new BD FACS Count System compared to the standard BD FACS Count system for count of lymphocytes TCD4. Methods: It was a comparative study conducted in Centre MURAZ research institute. The New BD FACS Count System dedicated to enumerate absolute and perc.. Read More
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Genotyping and Drug Resistance Patterns of M. tuberculosis in Eastern Amhara region, Ethiopia
Background: Ethiopia is among the countries with the highest incidence of tuberculosis (TB) and has a early incidence of 379 cases/100,000 population. Of the high TB burden regions, Amhara is the top. So understanding the epidemiology of TB through molecular genotyping techniques such as Spoligotyping have invaluable role to com.. Read More
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Clozapine for Treating Pharmacoresistant Schizophrenia among Elders
Introduction: Pharmacoresistant schizophrenia is not a rarity. It is defined as un successfull treatment of schizophrenia by two different sort of antipsychotics with different mechanism of action, lasting up at least six weeks with dosage which is equivalent to 1000 mg per day of chlorpromazine in the period of last five years... Read More
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