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The interaction between the epidermal growth factor receptor (EGFR) and N-glycolyl GM3 ganglioside (NeuGcGM3) and its contribution to the progression of tumors have been previously described. However, studies concerning to the double expression of EGFR and NeuGcGM3 in human tissues are scarce. Here, it was evaluated by immunohis.. Read More
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The occult infections are widely found in co-infections with viral agents of hepatitis C (HCV) and human immunodeficiency virus (HIV). These three viruses share similar transmission routes, so that cases of co-infections are common. People infected with HCV or HIV is more prone to infection occult. The cases of co-infections are.. Read More
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Background: Next generation sequencing (NGS) of selected genes is an expanding field of solid tumor characterization. Multiple vendors offer this service, but panel design and policies on interpretive reporting are variable. This study compared reports from selected vendors, with emphasis on clinical Action ability reporting.. Read More
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Objective: Progesterone receptor membrane component 1 (PGRMC1) is a novel membrane progesterone receptor that is highly expressed and actively regulated in gestational tissues. Research suggests that PGRMC1 plays a role in mediating progesterone function in gestational tissues and maintaining pregnancy. It has also been reported.. Read More
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Molecular Diagnosis of Brucellosis: A Brief Report
Amplification of nucleic acid by polymerase chain reaction (PCR) assays in order to diagnose infection by Brucella spp. has been used for more than two decades. Human Brucellosis is an endemic disease in many countries worldwide and often poses diagnostic puzzles. The implementation of PCR (standard, real-time and multiplex) can.. Read More
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Human Immunodeficiency Virus (HIV) patient management continues to be a challenge all over the world. CD4 absolute counts and viral load are the gold standard tools for monitoring of HIV-1 disease. However, the use of CD4 counts cannot be used solely to determine the overall status of immune system. It requires the additional me.. Read More
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The frequency of cerebral infarcts associated to a hematologic infection remains difficult to be known and imprecise. The deficit of S and C protein is rarely responsible for cerebral infarcts. We thus bring a young Ivorian patient hospitalized in our neurologic service. She consulted for a left hemi corporal motor deficit of a .. Read More
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Myasthenia gravis is a rare disease with very few confirmed cases described in the African setting. We report the case of a 41-year-old woman with a history of type 2 diabetes, high blood pressure (well monitored), and migraine with aura. She was received at the outpatient neurology consultation for a left ptosis, diplopia, chew.. Read More
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Shiga toxin-producing strains of E. coli are a significant cause of food-borne outbreaks of gastroenteric disease. The objective of this study was to evaluate loop-mediated isothermal amplification (LAMP) assays for the identification of Shiga toxin producing E. coli O157 (STEC) and non-O157 strains. Four LAMP assays were develo.. Read More
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RAC1b: A New Player in the Scenario of Thyroid Tumorigenesis?
Tumor-associated RAC1b overexpression has been recently highlighted as one promising target for therapeutic intervention in pancreatic, breast, colon and lung cancer. Recent data documenting RAC1b overexpression in a subset of papillary thyroid carcinomas, carrying the activating mutation BRAFV600E and associated with an unfavor.. Read More
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Molecular Diagnostics in Melanocytic Tumors: The Pathologists Perspective
During the last 15 years, molecular techniques have led to a fast gain in our knowledge on the development of melanocytic tumors. The potential implications of these advances for prognosis and therapy of melanoma patients are outstanding. There is, however, an even greater problem which has to be raised: since the histopathologi.. Read More
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Advancements in next-generation sequencing, variant-calling software, and mutation enrichment are facilitating the detection of rare genetic variants. In doing so, these methods have enabled identification of somatic disease, and more specifically cancer, representing as little as 0.01% of bulk genetic material. This improved se.. Read More
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