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Opinion Article Open Access
During the last 15 years, molecular techniques have led to a fast gain in our knowledge on the development of melanocytic tumors. The potential implications of these advances for prognosis and therapy of melanoma patients are outstanding. There is, however, an even greater problem which has to be raised: since the histopathological diagnosis of melanoma is matter of considerable disagreement even among experts . Pathologists have been increasingly asking for a molecular ‘key to the code’ in order to overcome the diagnostic limitations of conventional morphology. Table 1 summarizes the main molecular techniques and their expected results in melanoma , are these data meaningful also for the histopathological differential diagnosis between ‘nevus’ and ‘melanoma’?
Melanoma, Spitzoid melanocytic tumors, Histopathology, Molecular diagnostics, Cancer Progression and Diagnostics,Molecular Diagnostics