Make the best use of Researched information from 700+ peer reviewed, Open Access Journals operated by 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business
Stem Cell-Derived Neurons for the Treatment of Neurodegenerative Diseases
Neurodegenerative diseases are termed for the age-related chronic and progressive loss of structure and function of neurons. Most common neurodegenerative diseases include Alzheimer’s disease (AD) and Parkinson’s disease (PD). So far, no drugs can be used to reverse the neuronal degeneration. Recent progresses in ste.. Read More
To read the full article Visit Full Article | Download Full Article
Background: Great inter-individual variability exists in the susceptibility to gain weight during antipsychotic treatment. Thus, we examined whether the -759C/T variants in the promoter region of the 5HT2C receptor gene were differentially associated with weight gain in children and adolescents in long-term risperidone treatment.. Read More
To read the full article Visit Full Article | Download Full Article
Neurite outgrowth is primarily necessary step to construct a neuronal network. If this step is collapsed, neurons are died and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, which are known to induce endoplasmic reticulum (ER) stress-mediated apoptosis, are occurred. It has been elucidatin.. Read More
To read the full article Visit Full Article | Download Full Article
In vivo Interaction Studies of ACE Inhibitors with NSAIDs on Carrageenan Induced Inflammation
Both antihypertensive and non steroidal anti-inflammatory drugs are frequently prescribed together since hypertension and co-existing musculoskeletal problems are two of the frequent conditions. In vivo interaction studies of ACE inhibitors (enalapril, captopril and lisinopril) were carried out with commonly used NSAIDs (diclofe.. Read More
To read the full article Visit Full Article | Download Full Article
Pharmacokinetic parameters including AUC0-t, AUC0-∝, Cmax, Tmax, T1/2 and Elimination rate constant (Kel) were determined from plasma concentrations of Zaltoprofen spherical agglomerated dense compacts by 24 factorial design canvassed with a commercially available formulation of Zaltoprofen. Foremost spherical agglomerates .. Read More
To read the full article Visit Full Article | Download Full Article
Traumatic Brain Injury (TBI) and stroke are leading causes of neurological dysfunction and are major health concerns worldwide. Much research has been conducted on the processes at work in TBI and stroke; however, to date no pharmaceutical treatments have been shown to be effective in treating human clinical TBI and only one dru.. Read More
To read the full article Visit Full Article | Download Full Article
BDNF and Synaptic Plasticity: The Recent Cell Biology for Understanding of Brain Disorders
The cell biology of synaptic plasticity and neurotrophic factor has been extending to the understanding of pathological mechanisms of brain disorders. This knowledge could prove beneficial for the development of new therapies against brain diseases. Dendritic spines are actin-rich structures, which are part of most excitatory sy.. Read More
To read the full article Visit Full Article | Download Full Article
Recently, it was reported that some low-molecular-weight compounds mimic neurotrophic activities including neurite outgrowth and neuroprotection. Carnosic acid (CA) promotes neurite outgrowth through the activation of Nrf2 in a model of neuron PC12 cells. CA also protects neurons from oxidative stress via the keap/Nrf2 transcrip.. Read More
To read the full article Visit Full Article | Download Full Article
Infectious diseases caused by multi-resistant strains of Staphylococcus aureus are on the increase and fighting them with natural products may be more efficacious. The aim of this study was to investigate the in vitro antibacterial activity of methanol leaf extract and the solvent fractions of Phyllanthus muellerianus (Kuntze) E.. Read More
To read the full article Visit Full Article | Download Full Article
The main objective of the present work was to study the pharmacokinetic parameters and safety of the optimized aspirin suppositories and aspirin nanoparticles loaded suppositories and comparison both. ASA-nanoparticle prepared based on ionicgelation mechanism and optimized Fa9 formulation was isolated. ASA-suppositories prepared.. Read More
To read the full article Visit Full Article | Download Full Article
Pharmacogenomics-Guided Approaches to Avoiding Adverse Drug Reactions
Adverse drug reactions (ADRs) are one of the major causes of patient morbidity and mortality. Pharmacogenomics is the study of how individual response to drugs is affected by genetic mutations at the genome level. There is clinical evidence that polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters and dru.. Read More
To read the full article Visit Full Article | Download Full Article
Carboxypeptidase E (CPE) has recently been described as a neuroprotective protein, and in mice devoid of CPE, a complete loss of the hippocampal CA3 neurons is observed. The pattern of loss is characteristic of that caused by status epilepticus. We therefore set out to determine when this loss occurred, what might induce it and .. Read More
To read the full article Visit Full Article | Download Full Article
Extrafine Beclometasone Dipropionate and Formoterol in Single and Separate Inhalers
The aim of this study was to evaluate the pharmacokinetics and pharmacodynamics of single administration of extrafine beclometasone (BDP)/formoterol hydrofluoroalkane (HFA) (Foster®, Chiesi Farmaceutici S.p.A., Italy) by pressurized metered dose inhaler (pMDI) in healthy volunteers, compared to the free combination of ex.. Read More
To read the full article Visit Full Article | Download Full Article
Spine Homeostasis as a Novel Therapeutic Target for Schizophrenia
Schizophrenia is a complex disorder with positive, negative and cognitive deficits. Previously, great reduction in spine number has been reported in schizophrenia patients. Mutations in numerous genes that encode synaptic proteins are known as genetic risk factors. In addition, antipsychotic drugs change the number of spines, su.. Read More
To read the full article Visit Full Article | Download Full Article
Should Deubiquitinating Enzymes be Targeted for Therapy?
Effective, non-toxic therapies for many diseases, including malignancies, metabolic syndromes and age-dependent neurodegeneration remain elusive, though not for lack of effort from scientists all over the world... Read More
To read the full article Visit Full Article | Download Full Article
Direct Measurement of Lipase Inhibition by Orlistat Using a Dissolution Linked In Vitro Assay
Purpose: To develop a bio-assay that would be able to directly test gastrointestinal and/or dissolution samples to determine lipase activity and inhibition by Orlistat. Methods: Enzyme assays were performed with porcine pancreatic lipase and para-Nitrophenyl Palmitate (pNPP) in pH 8.0 reaction buffer at 37°C. Substrate hydr.. Read More
To read the full article Visit Full Article | Download Full Article
A simple, rapid, specific and sensitive liquid chromatography tandem mass spectrometric method has been developed and validated for the estimation of Ethambutol from 100 μL of human plasma. Ethambutol is extracted from human plasma by Protein Precipitation Extraction. Glipizide was used as an internal standard. Detection was .. Read More
To read the full article Visit Full Article | Download Full Article
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi