|Physical dependence is the state of the body when it becomes so dependent on a drug that the body cells cannot function without it. Withdrawal may lead to complications ranging from headache, vomiting , nausea to delirium, convulsions etc. substances which are capable of producing Physical dependence should not be stopped suddenly but the dose should be lowered gradually. Innovations are new idea, device or process. Innovations are the application of better solutions that meet new requirements, inarticulated needs or existing market needs. It is proficient through more effective products, processes, services, technologies, or new ideas that are readily available to markets, governments and society. Innovations are something original and novel, as a significant, new that âbreaks intoâ the market or society.