|Human Immunodeficiency Virus type 1 (HIV-1)-Associated Neurocognitive Disorder (HAND) is a major neurological complication of HIV infection, affecting up to 50% of persons with advanced HIV disease. With the introduction of combined antiretroviral therapy (cART) in the mid-1990s, HAND is persisting due principally to the increased life expectancy, and the chronic neurotoxic effect of HIV on the brain. Therefore, as for HIV infection, HAND is now considered a chronic disease in countries with cART access.
Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.
The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.