Eradication of HIV within the body therefore requires the difficult task of purging of such latently infected cells: Lehrman et al present proof that this is a feasible concept by using histone deacetylase 1 inhibitor (HDAC1) valporic acid to overcome the latency of integrated HIV genomes in resting CD4+ cells.
Infection of CD4+ cells with HIV leads to activation and up-regulation of cell surface proteins that further facilitate HIV entry, usually culminating in cell death through apoptosis. However, some activated cells survive and return to their resting state with HIV integrated into their genome and remain as a reservoir capable of HIV replication, and commonly persist even after intensive HAART. (Draining HIV reservoirs).
Last date updated on September, 2014