Many virological, immunological and pharmacological factors may play role in the development of ADR. First, the rate of viral duplication and turnover associated with HIV infection is too high. In addition, circulating viral quasi-species may be extremely heterogonous. In fact, the lack of proofreading and an infidel reverse transcriptase can give rise to a genotypically heterogonous horde of circulating viral quasi-species soon after the infection has been established. It is noteworthy that developing ADR requires accumulation of genomic changes within host bodily systems.
Last date updated on October, 2020