|Human Immunodeficiency Virus type 1 (HIV-1)-Associated Neurocognitive Disorder (HAND) is a major neurological complication of HIV infection, affecting up to 50% of persons with advanced HIV disease. With the introduction of combined antiretroviral therapy (cART) in the mid-1990s, HAND is persisting due principally to the increased life expectancy, and the chronic neurotoxic effect of HIV on the brain. Therefore, as for HIV infection, HAND is now considered a chronic disease in countries with cART access.
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