Alzheimers disease (AD) is an etiologically heterogeneous disorder. While many genes have been found to be associated with Early and Late onset AD, a large portion of the predicted heritability remains unidentified. Here we review AD pathology, with an overview of AD genetics. In addition, we review epigenetic mechanisms and the current literature that suggests a relationship between epigenetic mechanisms and AD pathology. The genome wide association studies conducted to date can explain a percentage of AD cases. The remainder may be best explained by complex interactions between epigenetic and environmental factors that differ between individuals.
The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information.
Last date updated on July, 2014