"ApoE4 is associated with pathological conditions including atherosclerosis and Alzheimerâs disease. During pregnancy, ApoE4 promotes atherosclerosis by elevating low density lipoproteins (LDL) levels as well as promoting thrombosis, as discussed earlier. The majority of the population expresses ApoE3 so t is inefficient marker of disease but high ApoE2 and ApoE4 levels is correlated with elevated risk of recurrent spontaneous abortion. Recent studies suggest ApoE levels are unaffected by preeclampsiabut polymorphisms result in misrepresentation of glycosylation isoforms in women with preeclampsia. The basic deglycosylated form is increased and the acidic isoform is decreased in preeclamptic women. This is a possible explanation for the conflicted reports of ApoE levels in women with preeclampsia because studies could be detecting different isoforms of ApoE due to different post-translational modifications.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."
Last date updated on July, 2014