Alzheimer disease is also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome/HRS, or paralysis agitans) is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. The last two decades have witnessed tremendous advances in understanding the biology of Alzheimer disease. Yet, no cure is available. Recent research has pinpointed gamma-secretase, one of the two enzymes responsible for beta-amyloid production, as the primary target to focus on. It has been shown that modulation of gamma-secretase is possible, and it is in theory possible to find the right modulator that will lead to the right cure. The key to success to do so is to clearly establish the right structure of the gamma-secretase within the membrane.
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Last date updated on December, 2020