|Alzheimerâs disease (AD) is the most common form of dementia,mainly occurring in the aged population (>65 years of age).Pathologically, AD consists of two major hallmarks: neurofibrillarytangles (NFTs) and senile plaques (SPs), which are comprised of hyperphosphorylatedtau (p-tau) filaments and amyloid-Î² protein (AÎ²)fibrils, respectively. Numerous reports suggest that AÎ² aggregation,namely the formation of AÎ² oligomers, is an early event precedingother pathological changes in AD. AÎ² is physiologically generatedfrom the cleavage of amyloid precursor protein by Î²- and Î³-secretasesin the endoplasmic reticulum (ER) and trans-Golgi network or in thelate endosome, then secreted into the extracellular space.
The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information.The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.