Alzheimerâs disease (AD) is the most common form of dementia,mainly occurring in the aged population (>65 years of age).Pathologically, AD consists of two major hallmarks: neurofibrillarytangles (NFTs) and senile plaques (SPs), which are comprised of hyperphosphorylatedtau (p-tau) filaments and amyloid-Î² protein (AÎ²)fibrils, respectively. Numerous reports suggest that AÎ² aggregation,namely the formation of AÎ² oligomers, is an early event precedingother pathological changes in AD. AÎ² is physiologically generatedfrom the cleavage of amyloid precursor protein by Î²- and Î³-secretasesin the endoplasmic reticulum (ER) and trans-Golgi network or in thelate endosome, then secreted into the extracellular space.
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Last date updated on October, 2014