|Alzheimer¬ôs disease (AD) is the most common form of dementia,mainly occurring in the aged population (>65 years of age).Pathologically, AD consists of two major hallmarks: neurofibrillarytangles (NFTs) and senile plaques (SPs), which are comprised of hyperphosphorylatedtau (p-tau) filaments and amyloid-√é¬≤ protein (A√é¬≤)fibrils, respectively. Numerous reports suggest that A√é¬≤ aggregation,namely the formation of A√é¬≤ oligomers, is an early event precedingother pathological changes in AD. A√é¬≤ is physiologically generatedfrom the cleavage of amyloid precursor protein by √é¬≤- and √é¬≥-secretasesin the endoplasmic reticulum (ER) and trans-Golgi network or in thelate endosome, then secreted into the extracellular space.
Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.
The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.