Neuropathology of AD in the very old demented subjects differs considerably in both intensity and distribution from that in younger age groups. Increased densities of neuritic plaques and NFTs are absent in non-demented patients over age 85-90, and there is considerable overlap in the pathologies found in demented and non-demented patients. The synergistic interaction between AÎ², tau, and Î±Syn, accelerating neuropathology and cognitive decline, has been summarized recently.
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Last date updated on July, 2014