Oxidative stress associated with high cholesterol diet causes a disturbance in the stabilization of endothelial nitric oxide synthase (NOS) enzyme activity and inhibits endothelial Ca++-dependent potassium channels leading to a marked decrease in the synthesis of endothelial NO which has a vascular protective role. possible protective effect of aliskiren on aortic tissue against oxidative stress of hypercholesterolemia in cholesterol-fed rats could be based upon its anti-hypertensive effect that is associated with inhibition of renin and hence there is an inhibition of Ang II production and its contributing effect with the damaging effects of ROS on different body organs and tissues. Atherosclerosis and deposition of cholesterol in vascular endothelial cells were previously found to be associated with all serious adverse effects of oxidative stress on vessels and vital organs in the body.
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Last date updated on July, 2014