The onset of delirium represents a prognostic negative factor on morbidity, mortality, functional and cognitive outcomes,and it may run a more chronic course. In fact, older people taking five or more medications are at higher risk of delirium and falls, independent of medication indications. The development of delirium related to drug administration. Delirium and confusional states are among the most common mental disorders encountered in patients with chronic medical illness. Drugs that are agonists or antagonists of a number of other neurotransmitters can produce delirium-like effects, although the precise role of these neurotransmitter systems is difficult to determine. Cerebrospinal fluid (CSF) studies of patients with delirium reveal alterations in neuropeptides (eg, somatostatin), endorphins, serotonin, norepinephrine, and GABA, among others.
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Last date updated on July, 2014