A recent comparison between AD, pre-AD and non-AD cases, classified according to current criteria, using neuropathology and detection of soluble, high-molecular-weight Aò aggregates in a large autopsy series showed elevated Aò in clinical AD compared to pre-AD and non-AD cases. This suggests that, in addition to more widespread AD-related pathologies, soluble Aò aggregates in the neuropil play a role in the conversion of Pre-AD to clinical AD. Interdisciplinary projects/ initiatives for the standardized assessment of clinical, neuroimaging, biomarker, and neuropathological data are currently under way.
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Last date updated on September, 2024
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