"Amyloidosis is a disorder associated with the aggregation of soluble amyloid prone protein into insoluble fibrils within the extracellular tissue. More than 25 proteins are known to form amyloid fibrils in humans. Amyloidosis results in massive protein accumulation eading to organ and tissue failure or to amyloid induced cell death as believed to occur in Alzheimerâs disease (AD). The amyloid fibrils exhibit a characteristic Ã-pleated sheet configuration, which histologically can be visualized using the amyloidophilic dyes Congo red or Thioflavine T. Several factors favor the formation of fibrils, such as high local protein concentration, low pH, proteolytic processing and chemical modifications by physiologically formed metabolites.
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Citation: Nielsen NS, Poulsen ET, Klintworth GK, Enghild JJ (2014) Insight into the
Protein Composition of Immunoglobulin Light Chain Deposits of Eyelid, Orbital and
Conjunctival Amyloidosis. J Proteomics Bioinform S8: 002"
Last date updated on July, 2014