Mandibular defects due to various conditions such as tumor excisions or injury are generally reconstructed using free bone grafts, pedicle bone grafts, microvascular free flaps, reconstruction plates, and Particulate Cancellous Bone and Marrow (PCBM) grafts. These methods have advantages and disadvantages in terms of morphological and functional recovery. Among these techniques, microvascular free bone grafts such as those involving the fibula or scapula are often used for a wide range of defects after resection of malignant tumors. However, these methods require specialized surgical expertise and hospital resources, and donor site morbidity is significant. There are also limitations in restoration of the complex shape of the mandible, particularly in terms of maintaining symmetry of the curve of the mental region. The goal of mandibular reconstruction is to recover the patientâs aesthetics and occlusal and masticatory functions so that the use of dentures and dental implants is possible. This implies the need to regenerate a mandible of the desired shape and sufficient strength.
In 1944, Mowlem demonstrated the superior osteogenic potential of cancellous bone grafts. However, sufficient global application of jawbone reconstruction in the clinical setting has not occurred. In 1964, Burwell reported that the cells capable of bone formation are included in PCBM originated from undifferentiated mesenchymal cells. Application of Regenerative Medicine to Mandibular Reconstruction: Kazuhiro Yagihara and Yukihiko Kinoshita
Last date updated on June, 2014