"The difficulty in regenerating damaged myocardial tissue has led researchers to explore the application of embryonic- and/or adultderived stem cells as possible cellular sources for the regeneration of cardiac myocytes to reconstruct the ischemically compromised
myocardium . Using stem cells, it has been possible to stimulate mammalian cardiac muscle regeneration and researchers have investigated the potential of adult bone marrow stromal cells (BMSCs) for cardiac tissue repair and/or regeneration. It is well established that postnatal bone marrow harbors a heterogeneous population of adult stem cells and precursor cells that includes hematopoietic stem cells (HSCs), bone marrow stromal cells or mesenchymal stem cells (BMSCs/ MSCs), multipotent adult progenitor cells (MAPCs) and endothelial precursor cells (EPCs). These cells have a unique combination of surface antigenic markers and have the potential to generate different sets of differentiated progeny. Adult stems cells, including BMSCs, exhibit a certain degree of developmental plasticity that enables them to differentiate across boundaries of lineage, tissue and germ layers. This differentiation potential of BMSCs has prompted exploration into the ability and capacity of these unique cells to differentiate into myocardium. (Mani T. Valarmathi and John W. Fuseler- Mammalian Cardiac Muscle Regeneration: Structural and Functional Modulation of Adult Marrow Stromal Stem Cells)"
Last date updated on June, 2014