A model of the interaction of MFG and the hippocampus to control memory accessibility is rather incomplete unless it can be detailed with more anatomical and functional specificity. Therefore, I attempt to illustrate this model using literature from comparative anatomy to include more fine grained neural aspects. The goal is to provide a testable model that can guide future research examining the control over memory accessibility, as well as how dysfunction is manifest within such neural pathways.
Taken from the neuroimaging results, one mechanism appears to be critical during attempts to control memory retrieval, the MFG-hippocampus interaction. Therefore, it is important to first illustrate the specific anatomical connections of the MFG and hippocampus. While the specific anatomical substrates have been somewhat overlooked in cognitive neuroscience, comparative anatomy/neurology has strongly supported a reciprocal connection of the MFG and hippocampus . The literature has primarily focused on three pathways connecting disparate parts of PFC and subregions of the hippocampal complex: the hippocampal-prefrontal, the lateral and the medial. All three pathways have been shown to contain reciprocal connections of the PFC and hippocampus in animals and humans. The hippocampal-prefrontal pathway primarily connects the medial prefrontal cortex to the hippocampal complex through regions of the basal ganglia and thalamus and is involved with output of the hippocampus to regions involved in dopaminergic transmission (e.g., nucleus accumbens). The lateral pathway directly connects MFG areas BA9/46 (dorsal/mid) to the anterior hippocampal comple and to the perforant path (all subfields of the hippocampus), considered the main route in which multimodal cortical pathways reach the hippocampus for subsequent encoding. While undoubtedly important for memory processes, these pathways either do not involve the MFG, or are more involved with hippocampal input and encoding and as such will not be focused on.
( Brendan E. Depue- Prefrontal â Hippocampal Interaction: An Integrative Review and Model of the Think/No-Think Task with Implications for Psychiatric Conditions)
Last date updated on June, 2014