Thalassemia is a disorder which is inherited from parents to children. Thalassemia is the most common type of hemoglubinopathies transmitted by hereditary. Thalassemia is classified into two major types, alpha and beta that are named after defects in these protein chains. The Î± thalassemias includes HBA1 and HBA2 genes. Î± Thalassemias involve in decreased alpha-globin production with fewer alpha-globin chains release continued with excess of Î² chains in adults and excess Î³ chains in new-borns. Beta thalassemiaâs is because of mutations in the HBB gene on chromosome. The severity of thalassemia occurs with complications of including iron overload, bone deformities and cardiovascular illness. The disorder results in excessive destruction of red blood cells, which leads to anemia. Untreated, thalassemia major leads to heart failure and liver problems. The open access journals are peer reviewed scholarly journals of Hypertension: Open Access. The top open access journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community. These journals are indexed with all their citations noted. The top open access journals are indexed in SCOPUS, COPERNICUS, CAS, EBSCO and ISI.
Last date updated on September, 2014