Thalassemia is a disorder which is inherited from parents to children. Thalassemia is the most common type of hemoglubinopathies transmitted by hereditary. Thalassemia is classified into two major types, alpha and beta that are named after defects in these protein chains. The Î± thalassemias includes HBA1 and HBA2 genes. Î± Thalassemias involve in decreased alpha-globin production with fewer alpha-globin chains release continued with excess of Î² chains in adults and excess Î³ chains in new-borns. Beta thalassemiaâs is because of mutations in the HBB gene on chromosome. The severity of thalassemia occurs with complications of including iron overload, bone deformities and cardiovascular illness. The disorder results in excessive destruction of red blood cells, which leads to anemia. Untreated, thalassemia major leads to heart failure and liver problems. Scholarly journal is a peer-reviewed journal in which scholarship relating to a particular academic discipline is published. Scholarly journals serve as forums for the introduction and presentation for scrutiny of new research, and the critique of existing research. Content typically takes the form of articles presenting original research, review articles, and book reviews. The term Scholarly journal applies to scholarly publications in all fields; this article discusses the aspects common to all academic field journals.
Last date updated on September, 2014