|"Annexin A2 also acts in the fibrinolysis pathway. Plasminogen was observed as upregulated in three studies, both tissue and serum, while one study of serum observed it as down regulated. While plasmin was not detected as differentially regulated in preeclampsia by any of the 12 studies, it is likely upregulated as well in this thrombolytic disease. Detection methods may not have aimed to discriminate between cleavage products resulting in plasmin not detected as differentially regulated in preeclamptic women. Further studies are required to confirm theexpression of proteins in the fibrinolysis pathway and how it affects the placenta during preeclampsia.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."