"Numerous researches have been carried out worldwide on molecular targets towards the development of newer antidiabetic agents like nuclear receptor PPAR-? (peroxisome proliferator-activated receptor gamma), human incretin-degrading enzyme DPP-IV (dipeptidylpeptidase IV), protein-tyrosine phosphatase 1B (PTP1B), etc. These therapeutic targets may improve the efficacy-to-safety ratio, resulting in durable maintenance of glycaemic control in the majorityof people with diabetes. Several structurally unrelated natural products, including alkaloids, flavonoids or organic acids had also been described to interact with these diabetic proteins in micromolar concentrations.
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Citation: Bharti SK, Kumar A, Prakash O, Krishnan S, Gupta AK (2013) Essential Oil of Cymbopogon Citratus Against Diabetes: Validation by In vivo Experiments and Computational Studies. J Bioanal Biomed 5: 194-203."
Last date updated on July, 2014