Thalassemia is a disorder which is inherited from parents to children. Thalassemia is the most common type of hemoglubinopathies transmitted by hereditary. Thalassemia is classified into two major types, alpha and beta that are named after defects in these protein chains. The Î± thalassemias includes HBA1 and HBA2 genes. Î± Thalassemias involve in decreased alpha-globin production with fewer alpha-globin chains release continued with excess of Î² chains in adults and excess Î³ chains in new-borns. Beta thalassemiaâs is because of mutations in the HBB gene on chromosome. The severity of thalassemia occurs with complications of including iron overload, bone deformities and cardiovascular illness. The disorder results in excessive destruction of red blood cells, which leads to anemia. Untreated, thalassemia major leads to heart failure and liver problems. The scope of Journal of Blood Disorders & Transfusion encompasses all aspects of Hematological disorders. It forms a close link between the clinical areas and the research units. Making papers freely available online provides the readers, researchers and the scientific professionals with the most current peer-reviewed scientific information and discoveries.
Last date updated on July, 2014