"Increase in GFAP content is related to differentiation in malignant gliomas also investigated the differentiation potential of many flavonoids and found that the rutin aglycone quercetin induced differentiation of rat neural PC12 cells but not rutin, suggesting that structural determinants were needed for differentiation activity induced by flavonoids. Finally the recent findings that astrocytes and microglia are targets for the flavonoid rutin, inducing activation and even the release of trophic factors such as TNF-alpha and nitric oxide may lead to the development of new therapy protocols based on stimulation of glial cells response against glioblastomas.
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Citation: Costa SL (2014) Antiglioma Potential of Flavonoides. J Bioanal Biomed 6: e124."
Last date updated on July, 2014