Numerous studies demonstrate that atherosclerotic lesion development occurs at the site of the blood vessel that is subjected to disturbed flow, such as the lesser curve of the aortic arch or at bifurcations. These observations have led researchers to hypothesize that different types of blood flow have different effects on the function of endothelial cells (ECs) that line the blood vessels and are directly exposed to hemodynamic forces. The major mechanical force is fluid shear stress, the frictional force on ECs generated by blood flow. Disturbed flow occurs when the fluid shear stress is not constant in magnitude or frequency. Mechanical forces that are associated with blood flow have been shown to be major initiating factors of vascular pathology. A region of the vasculature where shear stress is low is more likely to develop atherosclerosis. In addition, specific patterns of flow disturbance induced by flow separation, gradients, flow reversal and turbulence contribute to plaque formation. TF RNA expressions at 60 cpm in both combined stimulation of TFF and PFF with Th induces higher TF RNA expression that those of 30 cpm with Th, cells that are subjected to disturbed flow under chemical stimuli, the reaction to the change of the frequency seems to result in a non-linear increase in TF RNA expression.TF RNA expressions of HUVECs exposed to 60 cpm TFF with Th is still increasing significantly by 4 hours, while those exposed to 30 cpm reach peak expression by 2 hours. OMICS Group International is one of the leading Open Access Publishing houses, which has around 700+ peer-reviewed journals, 50,000+ editorial board members, and highly qualified, expert reviewers to meet the objectives of the Peer-Review Process. OMICS Group International peer-review policies are highly appreciated, accepted and adaptable to the criteria that have been prescribed by the international agencies such as NIH, PubMed etc. OMICS Group International also organizes 3000+ International Scientific Conferences per year globally.
There is a great deal of information out there on scientific topics. However, whether it can be trusted or not is a key issue at present. The main question that often emerges in this aspect is about the review process adopted to screen the articles for publication. One of the most acceptable and proven process adopted in majority reputed international journals is peer reviewing.
Benefits of peer-review:
â¢ Establishes the legitimacy of exploration based upon the expert information of different specialists in the order, consequently averting adulterated work from being acknowledged within an area of study.
â¢ Provides significant criticism with the intention that scientists can revise and enhance their papers before Publication.
â¢ Enables Journal editors to select the most important research findings for publication in their journals, based upon the subject, independent reviews of an expert group.
Last date updated on July, 2014