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Kazuhiko Watabe | OMICS International
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Kazuhiko Watabe


Physiological and Pathological Roles of Aldose Reductase in Schwann Cells

Aldose reductase (AR), the first enzyme in the polyol pathway, is predominantly localized to Schwann cells in the peripheral nervous system (PNS). The exaggerated glucose flux into the pathway via AR in Schwann cells under diabetic conditions is thought to be a major contributing factor in the pathogenesis of diabetic neuropathy, and the restoring ... Read More»

Kazunori Sango, Koichi Kato, Masami Tsukamoto, Naoko Niimi, Kazunori Utsunomiya and Kazuhiko Watabe

Mini Review: J Mol Genet Med 2014, S1: 012

DOI: 10.4172/1747-0862.S1-012

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF